See for more information about the mixture, and for information about the various mixtures of amphetamine currently marketed. New York, USA: McGraw-Hill Medical. Following amphetamine uptake at VMAT2, amphetamine induces the collapse of the vesicular pH gradient, which results in the release of dopamine molecules from into the cytosol via dopamine efflux through VMAT2. However, by the 1930s, amphetamine was being recommended for a variety of ailments. Historically, it has been used to treat nasal congestion and depression. Also, when considering the potency of 3-Methylfentanyl, you have to consider that when you make it, you actually have four isomers, and only one of those posesses the extreme potency. Phenethylamine is the parent compound of amphetamine, while N-methylphenethylamine is a of amphetamine that differs only in the placement of the. Did anyone ask for advice? If intestinal activity is high, amphetamine may reduce the rate at which content moves through the digestive system ; however, amphetamine may increase motility when the of the tract is relaxed.